The Philadelphia Phillies host the Houston Astros in the second match of their mini-series on Tuesday night. The Phillies lead the series 3-2 after an opening night win on Monday. In our latest MLB betting picks we tell you if the Astros will level the series, or if the Phillies will go into an unassailable 2-0 lead.
Tuesday’s fixture is the second of a three-match interleague mini-series between the Philadelphia Phillies and the Houston Astros. The mini-series is at Citizens Bank Park, Philadelphia’s home venue. The Phillies lead the NL East, the Astros are top of the AL West. They are two of the in-form franchises in the MLB.
Tonight’s fixture is the second match of a seven-fixture home run for the Phillies. After the three matches against the Astros, they host the Atlanta Braves in a four-match mini-series.
The Phillies have a six-match lead over the Atlanta Braves in the NL East. As a result, they are -2500 to win the division. In the betting to win the 2025 World Series, Philadelphia is the third favorite at +500.
As for the Astros, this series marks the end of seven matches on the road. At the conclusion of this series, they will face the Kansas City Royals at Minute Maid Park in a best-of-four mini-series starting on Thursday.
Houston has a smaller lead in their division. They lead the Mariners by 3.5 games. In the betting to win the AL West, Houston is -800. The Mariners are +425.
To win the 2025 World Series, Houston is +1300.
To win the second fixture of the series, Philadelphia is the odds-on favorite at -140 on the money line. To win on the road, the Astros are +125.
On the run line, the Astros are receiving a +1.5-run start. To win with the handicap in their favor, Houston is -165. To win and cover the 1.5-run spread, Philadelphia is +145.
On the total runs line, over 8.5 is the favorite at -120. Under 8.5 is +100.
Our odds are from the best MLB World Series betting sites. More Phillies vs. Astros betting options can be found on our baseball odds table.
| Phillies vs. Astros |  |  |  |
|---|---|---|---|
| Phillies | -140 | -140 | -140 |
| Astros | +125 | +125 | +125 |
| Phillies (-1.5) | +145 | +145 | +145 |
| Astros (+1.5) | -165 | -165 | -165 |
| Over 8.5 | -120 | -120 | -120 |
| Under 8.5 | +100 | +100 | +100 |
The most recent fixture between the two franchises was on Monday night.
In a closely fought match, a Bryce Harper walk-off single in the 10th innings was the difference between the two franchises.
It was a match that could have gone either way, and this is how we see the rest of this series going.
In their last ten fixtures, the Phillies are 6-4. At home, their record is an impressive 43-23. Overall, the Phillies are 77-54.
Monday night’s win over the Astros was the Phillies third successive win. It was also their fifth home win in six matches.
The Astros are 5-5 in their last ten matches. On the road, their record is 35-32, and overall, they are 71-60. The Astros are 2-3 in their last five on the road. But in their most recent 13, they are 10-3 on the road.
The Astros recently went on a nine-match winning streak on the road. Their remarkable run only ended in their last series away to the Orioles.
The nine-match run included two wins over the Texas Rangers. Then there were back-to-back three-match sweeps of the Red Sox and the Rays. Finally, a 6-0 win over Baltimore in game one of their shared four-match series.
The Astros did lose a three-match home series to the Red Sox ahead of the 2-2 series draw with the Orioles. It’s hard to know whether the recent slump is limited to just a home-field problem, or whether it is something more serious.
Six of the Phillies’ last ten matches have been under 8.5 points. And six of the Astros’ last ten matches have also been under.
These are two evenly matched-teams, and we expect another close encounter tonight at Minute Maid Park.
The top-rated MLB betting sites favor over, which means we are getting better value on under at +100.
Under 8.5 points is the betting pick.
Onto our match-winner pick and as we just mentioned, we are expecting a close encounter. The Astros haven’t gone 2-0 down in a series since they were turned over by the Pirates at Minute Maid Park at the end of July.
That’s a good run. And the series win for the Pirates was a shock result. The Astros won’t want to let one of their World Series-winning rivals take too much initiative over them. Philadelphia may well go on and win the series, but if they do, we say it will be in a series-deciding match.
We are backing the Houston Astros to bounce back with a win. The odds are in their favor at +125, and they have a good record on the road.
Check below for our list of the Top-Rated Sportsbooks for Online Sports Betting:
About the Author
Dean is primarily a fan of English football who regularly attends games, and combining his hobby with his job, he is now a full-time sports betting writer. Rather than going down the educational route into sports journalism, Dean learned his trade by writing for his English football betting website since 2009, where he now boasts nearly 15 years of experience. After writing about football daily for years, Dean has taken the skills he learned and now uses them to great effect writing for numerous affiliate sites across the internet. A general all-around sports enthusiast with a passion for English football and cricket, Dean is also well able to turn his hand to writing about golf, tennis, F1, boxing, snooker, darts, and North American sports. Combining his extensive knowledge and experience with British humor and wit, Dean has developed into a trusted voice within the sports betting industry.
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